i'm currently running nfsfans 3/5 rom, 6.5 rom (v1.05) with sense 2.5 (manila 2.5) and i have been running it since he released this in march. great battery and seems quick. won't be as fast as a 6.1 rom with an older version of manila but if thats what your looking for you may as well stick with a stock rom.
as far as a 6.1 with sense 2.1, i don't think i ever found one.
give the nfsfans rom a try and see what you think:
http://forum.ppcgeeks.com/showthread.php?t=98809
this is what i am running and recommending to my friends.