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You MIGHT be able to do it with CodeWeavers Crossover Mac. It's a Mac app that lets you run Windows apps without Windows. I think it's basically a pretty version of Wine. Again, I'm not sure if this would work because I don't know how Crossover Mac interacts with ActiveSync and USB connected devices. Your best and safest bet would probably still be Boot Camp, Parallels, or VMware Fusion on an Intel Mac, or Microsoft Virtual PC if you're using a PPC based Mac.
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