Pre causes PC to crash???

[z28marols1]

So... heres something thats baffling me. Every time I plug my Pre into my PC via USB to transfer files over (using either USB mode or media sync mode) both my Pre and my PC start to lock up. My other USB peripherals on my PC start randomly working and not working (mouse and keyboard included). The only way I can get anything back is to unplug the USB cable and restart the PC and the Pre. Any clues as to what I'm doing wrong or what a possible remedy is would be greatly appreciated. Running latest version of WebOS and Vista Ultimate. I have never had any issues regarding my USB ports before and have tried on multiple ports. TIA!