I'm a fan of iGO8 (used TT7, Garmin XT, Copilot, Route66, iGuidance). Even though you can use different skins to your liking, it is a little busy with features and whatnot. Recently tested iGO Amigo and really like it. I'm not a heavy GPS user so it had just enough features for me. Main menu is similiar to iGO8 simple mode. Navigation screen is cleaner without the extra info iGO8 displays (just current turn, next turn, street and distance w/ time left & arrival toggle). Very clean and simple. Tons of screens on their site to compare:
http://www.i-go.com/amigo/