[bridic]

Yes it is.

Remap Manila softkeys:
HKLM/Software/HTC/manila/
HomeLSKPath, which is the left softkey (Standard = Phonepad)
And
HomeRSKPath, which is the right softkey.
If you change these with the location of the programs you want to link to, and simultaneous change the names:
HomeLSKText = Left softkey text
And
HomeRSKText = Right softkey text.

HKLM/Software/HTC/manila/
HomeRSKPath: \Program Files\iContact\iContact.exe
HomeRSKText: iContact