Now, to backup a key before modifying, which you should ALWAYS do, you highlight the "folder" in question on the left, go to edit, export...and save it somewhere safe. Choose the default options when saving it. It should be noted I get these stup[id little exception errors every now and then in CERegEditor, but they don't see to hurt anything. Could be a problem, on my end, but an FYI.
Now to edit something, right click the value on the right and choose edit.