I was having this problem, but I played around with the Settings/System/Key Lock settings, changing it first to Do not lock buttons, then back to Lock all buttons except Power button. Seems to be better since I did that.
Been running around in areas with low service all day...not sure if that has anything to do with the problem.
Edit: Cooked Verizon rom with S2U running.
Edit 2: Scratch that....took a while but it locked up again