I'm also very interested in hearing what everyone else is doing with their settings. In terms of video, I've left it pretty much stock as I haven't had many complaints (I can't expect HD video from this thing, as sweet as it would be...). Audio, however, is a very different story. I have to say, this is one of the few areas that makes me miss my Q. That thing had a hell of a pair of speakers. The 6800's speaker (note: singular... !) is almost abysmal in comparison.
I've done what I can with the equalizer, but I feel there is only so much potential there. Enabling volume normalization helps a bit, but without the bass, the best part of nearly every Nine Inch Nails, Garbage or Depeche Mode song I have on it is ruined! Why even bother with liking music that's heavy on post-production now?