i'm with most of this...
s2u2
resco
weatherpanel
threaded sms
photo dialer
tcpmp with flash video bundle (2 separate installs)
pocketcm (scroll w finger>scroll w knob)
led killer 3.1 (a MUST have, for me. it's the first one on in a flash)
things i tried that just really weren't my style (but a lot of people like):
htc home
htc home customizer
minimo
any cube setup
things i want, but still haven't done:
a custom lightweight kitchen w new radio/gps function
i also highly recommend an application like orb, if you want to watch/listen to your media stored on your pc, on your phone. it's wicked cool
and, don't forget to go through and mess with a lot of registry 'tweaks', once you get a registry editor. you'll be able to modulate a lot of the characteristics that can make your phone take better pictures, answer the phone faster, blah blah blah)