One thing I don't like about the home screens is the rigid 4x4 grid. I was primarily a MobileShell user under WinMo, and the layouts were very free-form. Allowed a lot of creativity in design. I've found a few things that get me close to this:
More Icons:
http://www.ree-yees.com/node/40
Puts 4 Icons into a 1x1 grid. Has several widgets that will allow you to put up to 16 icons/toggles into a 4x1 (complete row) space.
Launch-X
http://android.yuvalsharon.net/launchx.php
I like the look of this one better than More Icons, but I had already purchased More Icons. I might still buy this one. More Icons has system toggles (bluetooth, Wifi, etc) that Launch-X doesn't appear to support. Launch-X does support some really cool multiple page options and layouts.
Both can be found in the market.
When I get real fancy, I will figure out how to post QR codes to these things