Here is my Android Home Screen.
I have contacts I call the most around the outside for easy access to call/text/e-mailing. I use Launcher Pro Beta to have all my applications along the bottom 4 icons. In the newest version of Launcher Pro you can swipe across and display 4 different icons (similar to swiping between desktops). I can highly recommend trying it out. Finally I have my power strip in the middle. I don't use the other 2 desktops right now - this has everything I need.