So long as you don't need the HTC Sync software on the Mac, you should be able to do it exactly like you would for a Windows based machine. All of the Zip files and the likes are for the phone, not the OS. The only thing that's OS dependent is the ADK.
Here's the tutorial I used...
http://forum.xda-developers.com/showthread.php?t=701004
All of the files you'll need for the phone are in that thread. Everywhere it's got something in Windows, you'll just have to do on the Mac. Really there's not much in the way of computer interaction, it's mainly using the ADB tools.