On your home computer go to
www.orb.com. It'll take you through the entire set-up process. After your initial set-up it's just a matter of signing on to your ORB account from another computer (e.g., work) or your Treo, etc.
I have set up playlists on my home pc and listen to them at work and through my phone. ORB will work with just about any media you can throw at it.
Later,
Coz