Yeah, sure it is. Here's an example of the soft key mapped to the camera:
Code:
[HKEY_LOCAL_MACHINE\Software\HTC\Manila]
"HomeRSKArguments"="-P1" ;What parameters you want the file to execute
"HomeRSKPath"="\\Windows\\camera.exe";The path for the file
"HomeRSKText"="Camera" ;What will show on the soft-key