I was having all the same problems that most everyone else has been having with the "not waking from sleep mode for calls or anything else". I've disabled the HTC Home application from my today screen and haven't had to soft reset since. I tried disabling one application at a time, and found that nothing worked until I disabled HTC Home.
I really like the application, but if that's what it takes then oh well. Hopefully they'll have an update that fixes this so I can use it again one day. Hope this helps.
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