This is an issue with the HTC 6 tab plugin. It has been fixed with more recent versions, though.
Try installing the HTC Home plugin found here:
http://forum.ppcgeeks.com/showthread...ome+Customizer
It has the updated version under the heading "Windows Mobile 6 (Tested on Titan) 6Tab Home Plugin"
But make sure you uninstall the version you have now, and do a soft reset before installing the new version. I tried just installing over the old version and still had the profile switching problem.