I did that "Cleanup" file from this thread:
http://forum.ppcgeeks.com/showthread.php?t=84404
And the problem with switching to landscape with S2U2 has COMPLETELY stopped, and I haven't made ANY changes to the S2U2 settings. But one of the changes the cleanup file did was disable the device from automatically turning on when you slide out the keyboard. Not sure if this is related, but it sure seems like it may have something to do with it.
So besides that possibility, has anyone else been able to figure anything else out?