G-profile is the best, it will change volume, screen brightness, orientation, turn radios on and off, pretty much any setting you can think of based on time, location, equipment such as ac power, headset, handsfree, or even based on programs running. On top of all that it looks really good. It will even execute apps etc when switching profiles, this feature combined with Mortscript pretty much makes the possibilities limitless. Last but not least, it is free.
http://www.ageye.de/index.php?s=gprofile/about