I think most of the common reg edits are in the ROM [disable face down muting, etc], but definitely snoop around Google for others.

There's a thread here in PPCGeeks about radios...different radios can really help out battery life, but which to use is heavily dependant on where you live. That thread, I believe, has some discussions on what radios worked decent in certain locations that users reported out on.

Other than that, use Advance Config [cooked into the ROM} to disable your data connectino after 1 minute, and make sure your email clients aren't set to check every 5 minutes.

...if you're like me and near a charger most of the time, I think you'll be ok. Roaming is usually the only battery killer for me, but learning more about radios is helping to address that.