[csciguy]

This may not apply to your problem but it fixed my issue after installing and then later uninstalling CHT (cookies home tab).

I got this from their FAQ's:
"Q: After uninstaling CHT, sense doesn't work, or it works but the home menu doesn't come up.
A: Copy \windows\home_pages.xml to \windows\manilaxml\home_pages.xml (overwrite existing file). Then delete \windows\manilafull.xml and soft reset."

This worked for me twice.
The first thing I do is go to SETTINGS->HOME(Today)-->ITEMS
Uncheck HTC SENSE click OK.
Make these changes, I use TOTAL COMMANDER. REBOOT. CHECK HTC Sense again and it loads fine.
I hope this helps.